It has been known for some time that it was more likely the fleas of the rats rather than the rats themselves which spread the plague in 1348-49 leading to the death of about 30% of the population in Europe.
An interesting recent article on the issue which takes off the blame from the fleas as well:
Black Death study lets rats off the hook | World news | The Guardian
How much can the lack of any hygiene be attributed to a spread of plague as a city like London was already a very densely populated urbanised place already in the 14th century?



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